Description

3-(3,4-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and development, particularly in the creation of novel pharmaceutical candidates targeting central nervous system and other therapeutic areas. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for complex multi-step syntheses.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, especially in the development of receptor modulators and enzyme inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical entities.
• Building Block for Biologically Active Molecules: Facilitates the introduction of the difluorophenyl-piperazine moiety, a privileged structure in drug discovery.
• Agrochemical Synthesis: Intermediate in the development of new active ingredients for crop protection products.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for custom chemical synthesis projects.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	3-(3,4-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886768-81-6
Molecular Formula	C15H20F2N2O2
Molecular Weight	298.33 g/mol
Synonyms	1-Boc-3-(3,4-difluorophenyl)piperazine; tert-Butyl 3-(3,4-difluorophenyl)piperazine-1-carboxylate; 3-(3,4-Difluorophenyl)-1-(tert-butoxycarbonyl)piperazine; 1-(tert-Butoxycarbonyl)-3-(3,4-difluorophenyl)piperazine; 3-(3,4-Difluorophenyl)piperazine-1-carboxylic acid tert-butyl ester; N-Boc-3-(3,4-difluorophenyl)piperazine; BOC-3-(3,4-Difluorophenyl)piperazine; 886768-81-6
EINECS	Contact for details

Quality Control

Our 3-(3,4-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.