Description

3-(2,6-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative serving as a critical building block in modern organic synthesis. Its core value lies in providing a versatile, fluorinated aromatic scaffold with a Boc-protected secondary amine, enabling precise and efficient construction of complex molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating new active ingredients where the difluorophenyl and piperazine motifs are key pharmacophores.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, leveraging the stability of the fluorinated aromatic ring.
• Chemical Biology & Proteomics: Serves as a versatile linker or scaffold for designing chemical probes and enzyme inhibitors.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials requiring specific fluorine-containing monomers.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects requiring complex, multi-step organic transformations.

Basic Information

Product Name	3-(2,6-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886768-73-6
Molecular Formula	C15H20F2N2O2
Molecular Weight	298.33 g/mol
Synonyms	tert-Butyl 3-(2,6-difluorophenyl)piperazine-1-carboxylate; 1-Boc-3-(2,6-difluorophenyl)piperazine; 3-(2,6-Difluorophenyl)-1-(tert-butoxycarbonyl)piperazine; 1-N-Boc-3-(2,6-difluorophenyl)piperazine; 886768-73-6; 3-(2,6-Difluorophenyl)piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 3-(2,6-difluorophenyl)-1-piperazinecarboxylate
EINECS	Contact for details

Quality Control

Our 3-(2,6-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.