Description

3-(2,4-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine core and difluorophenyl substituent. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) and oncology targets.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial precursor in multi-step synthetic routes for final API manufacturing.
• Medicinal Chemistry & Drug Discovery: Used in structure-activity relationship (SAR) studies and library synthesis for high-throughput screening.
• Chemical Biology Research: Employed as a probe or linker in the development of biochemical tools and diagnostic agents.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.

Basic Information

Product Name	3-(2,4-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886768-57-6
Molecular Formula	C15H20F2N2O2
Molecular Weight	298.33 g/mol
Synonyms	tert-Butyl 3-(2,4-difluorophenyl)piperazine-1-carboxylate; 1-Boc-3-(2,4-difluorophenyl)piperazine; 3-(2,4-Difluorophenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-3-(2,4-difluorophenyl)piperazine; N-Boc-3-(2,4-difluorophenyl)piperazine; 886768-57-6; 3-(2,4-Difluorophenyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 3-(2,4-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for pharmaceutical R&D and synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.