Description

3-(2,3-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative serving as a critical building block in modern organic synthesis. This compound is essential for medicinal chemistry research and development, enabling the creation of novel pharmacologically active molecules. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and oncology drug discovery.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for the development of novel active pharmaceutical ingredients (APIs), especially those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to introduce the difluorophenyl-piperazine pharmacophore.
• Library Synthesis: Employed in the parallel and combinatorial synthesis of diverse compound libraries for high-throughput screening in drug discovery.
• Custom Synthesis: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom fine chemicals for clients.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) protecting group allows for selective manipulation of the piperazine nitrogen in multi-step synthetic sequences.

Basic Information

Product Name	3-(2,3-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886768-49-6
Molecular Formula	C15H20F2N2O2
Molecular Weight	298.33 g/mol
Synonyms	1-Boc-3-(2,3-difluorophenyl)piperazine; tert-Butyl 3-(2,3-difluorophenyl)piperazine-1-carboxylate; 3-(2,3-Difluorophenyl)-1-(tert-butoxycarbonyl)piperazine; 1-N-Boc-3-(2,3-difluorophenyl)piperazine; 886768-49-6; Piperazine-1-carboxylic acid, 3-(2,3-difluorophenyl)-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-(2,3-Difluoro-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.