Description

3-(3-Trifluoromethoxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative that serves as a critical building block in modern synthetic chemistry. Its molecular structure, featuring a trifluoromethoxy-substituted aromatic ring and a Boc-protected piperazine, makes it an essential intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of central nervous system (CNS) active compounds, including potential antidepressants, antipsychotics, and anxiolytics.
• Agrochemical Research: Used as a building block for developing new-generation pesticides and herbicides, leveraging the bioactivity of the trifluoromethoxy and piperazine motifs.
• Chemical Biology & Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and library synthesis for drug discovery programs targeting GPCRs and other protein families.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates and APIs under cGMP conditions for clinical trial materials.
• Material Science: Potential monomer or additive for specialty polymers where fluorine-containing groups impart unique surface properties and stability.

Basic Information

Product Name	3-(3-Trifluoromethoxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886768-33-8
Molecular Formula	C16H21F3N2O3
Molecular Weight	346.35 g/mol
Synonyms	1-Boc-3-(3-(Trifluoromethoxy)phenyl)piperazine; tert-Butyl 3-(3-(Trifluoromethoxy)phenyl)piperazine-1-carboxylate; 3-(3-Trifluoromethoxyphenyl)piperazine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-(3-trifluoromethoxyphenyl)piperazine; N-Boc-3-(3-Trifluoromethoxyphenyl)piperazine; 886768-33-8; 3-(3-(Trifluoromethoxy)phenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 3-(3-Trifluoromethoxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data including HPLC purity, NMR, and MS confirmation. Certificates of Analysis (COA) detailing all specifications are available for every batch and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.