Description

3-(3-Methoxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers requiring reliable, high-quality intermediates for complex multi-step syntheses.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, especially serotonin receptor modulators and other neuroactive compounds.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Synthesis: Serves as a protected amine component in multi-step organic reactions, including amide coupling and nucleophilic substitution.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of clinical trial materials and APIs.
• Academic Research: Utilized in university and institutional labs for methodological development and the study of heterocyclic chemistry.

Basic Information

Product Name	3-(3-Methoxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886768-09-8
Molecular Formula	C16H24N2O3
Molecular Weight	292.38 g/mol
Synonyms	tert-Butyl 3-(3-methoxyphenyl)piperazine-1-carboxylate; 1-Boc-3-(3-methoxyphenyl)piperazine; 3-(3-Methoxyphenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-3-(3-methoxyphenyl)piperazine; 886768-09-8; 3-(3-Methoxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 3-(3-Methoxy-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports applications in regulated environments, including pre-clinical and early-phase clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.