Description

2-(4-Trifluoromethyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative that serves as a critical building block in modern organic synthesis. Its core value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the pharmaceutical sector. This compound is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and psychiatric drug discovery programs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced biological activity and metabolic stability.
• Ligand and Catalyst Synthesis: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.
• Material Science: Potential monomer or additive in the development of advanced polymers with specific thermal or optical properties.

Basic Information

Product Name	2-(4-Trifluoromethyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886767-97-1
Molecular Formula	C16H21F3N2O2
Molecular Weight	330.35 g/mol
Synonyms	1-Boc-4-(4-(trifluoromethyl)phenyl)piperazine; tert-Butyl 4-[4-(trifluoromethyl)phenyl]piperazine-1-carboxylate; N-Boc-4-(4-Trifluoromethylphenyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(4-trifluoromethylphenyl)piperazine; 4-(4-Trifluoromethylphenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; Boc-4-(4-CF3-Ph)-piperazine
EINECS	Contact for details

Quality Control

Our 2-(4-Trifluoromethyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) detailing purity, impurity profile, and physical characteristics are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.