Description

3-(3-Trifluoromethyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly within the central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting neurological receptors.
• Agrochemical Research: Used in the development of advanced crop protection agents and pesticides due to its unique trifluoromethylphenyl moiety.
• Ligand Synthesis: Employed in the creation of specialized ligands for catalysis and biochemical assays.
• Chemical Biology Probes: Utilized to build molecular tools for studying protein interactions and cellular pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.
• Academic & Industrial R&D: Fundamental research reagent in universities and corporate labs for heterocyclic and fluorine chemistry.

Basic Information

Item	Details
Product Name	3-(3-Trifluoromethyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886767-85-7
Molecular Formula	C16H21F3N2O2
Molecular Weight	330.35 g/mol
Synonyms	1-Boc-3-(3-(trifluoromethyl)phenyl)piperazine; tert-Butyl 3-(3-(trifluoromethyl)phenyl)piperazine-1-carboxylate; 3-(3-Trifluoromethylphenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; 1-N-Boc-3-(3-trifluoromethylphenyl)piperazine; 3-(3-(Trifluoromethyl)phenyl)piperazine-1-carboxylic acid tert-butyl ester; BOC-3-(3-TRIFLUOROMETHYLPHENYL)PIPERAZINE; 886767-85-7
EINECS	Contact for details

Quality Control

Our 3-(3-Trifluoromethyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring suitability for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.