Description

3-(2-Trifluoromethyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-value, protected piperazine derivative that serves as a critical building block in modern organic synthesis. Its core value lies in its role as a versatile and protected synthetic intermediate, enabling the efficient construction of complex molecules for advanced research and development. This compound is primarily needed by pharmaceutical, agrochemical, and advanced material scientists engaged in the discovery and development of new active ingredients, where its trifluoromethylphenyl and Boc-protected piperazine moieties offer significant structural and functional advantages.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) targets, receptor modulators, and bioactive molecules containing piperazine scaffolds.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Chemical Biology & Proteomics: Employed as a building block for creating molecular probes, enzyme inhibitors, and tool compounds for biological pathway investigation.
• Material Science: Serves as a monomer or functional additive in the synthesis of specialty polymers and advanced organic materials with tailored properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for use in multi-step synthetic routes requiring a high-purity, protected intermediate.

Basic Information

Product Name	3-(2-Trifluoromethyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886767-77-7
Molecular Formula	C16H21F3N2O2
Molecular Weight	330.35 g/mol
Synonyms	1-Boc-3-(2-(trifluoromethyl)phenyl)piperazine; tert-Butyl 3-[2-(trifluoromethyl)phenyl]piperazine-1-carboxylate; 3-(2-Trifluoromethylphenyl)piperazine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-(2-trifluoromethylphenyl)piperazine; BOC-3-(2-Trifluoromethylphenyl)piperazine; 886767-77-7; 3-(2-(Trifluoromethyl)phenyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-(2-Trifluoromethyl-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.