Description

2-(4-Bromo-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine core and a brominated aromatic system. This compound is critical for medicinal chemistry research and development, enabling the synthesis of targeted bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology sectors for creating novel drug candidates, particularly in CNS and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting serotonin and dopamine receptors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile piperazine scaffold.
• Process Chemistry Development: Serves as a critical starting material for scaling up the production of active pharmaceutical ingredients (APIs) under GMP conditions.
• Library Synthesis: Employed in combinatorial and parallel synthesis to generate diverse chemical libraries for high-throughput screening.
• Bioconjugation & Probe Development: The bromo-phenyl group allows for further functionalization via cross-coupling reactions, useful for creating biochemical probes.
• Academic Research: Used in university and institutional labs for fundamental studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	2-(4-Bromo-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886767-73-3
Molecular Formula	C15H21BrN2O2
Molecular Weight	341.25 g/mol
Synonyms	1-Boc-4-(4-Bromophenyl)piperazine; tert-Butyl 4-(4-Bromophenyl)piperazine-1-carboxylate; 4-(4-Bromophenyl)-1-(tert-butoxycarbonyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(4-bromophenyl)piperazine; N-Boc-4-(4-bromophenyl)piperazine; 886767-73-3; 4-(4-Bromophenyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 2-(4-Bromo-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.