Description

1-Boc-3-o-Tolylpiperazine CAS NO 886766-65-0 is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and pharmaceutical development, enabling the creation of novel drug candidates with targeted therapeutic effects. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Scaffold: Used to explore structure-activity relationships (SAR) by introducing diverse substituents onto the piperazine core.
• Library Synthesis: Employed in high-throughput and combinatorial chemistry to generate focused libraries of novel compounds for biological screening.
• Agrochemical Research: Serves as a building block for developing new crop protection agents and pesticides.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up under cGMP conditions.

Basic Information

Product Name	1-Boc-3-o-Tolylpiperazine
CAS No.	886766-65-0
Molecular Formula	C16H24N2O2
Molecular Weight	276.38 g/mol
Synonyms	1-Boc-3-(2-methylphenyl)piperazine; tert-Butyl 3-(2-methylphenyl)piperazine-1-carboxylate; 3-o-Tolylpiperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-(2-methylphenyl)piperazine; N-Boc-3-(2-methylphenyl)piperazine; 886766-65-0; BOC-3-O-TOLYLPIPERAZINE; 1-Boc-3-(o-tolyl)piperazine
EINECS	Contact for details

Quality Control

Our 1-Boc-3-o-Tolylpiperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, NMR for structural confirmation, and Karl Fischer titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.