Description

(R)-1-Boc-2-Phenylpiperazine is a high-purity chiral building block and intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key precursor for the development of novel pharmaceutical compounds, particularly in the creation of active pharmaceutical ingredients (APIs) with specific stereochemistry. This product is essential for research and development chemists and process scale-up teams within the pharmaceutical, agrochemical, and fine chemical industries who require a reliable source of enantiomerically pure intermediates.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders, oncology, and other therapeutic areas.
• Asymmetric Synthesis: Used in the construction of complex molecules where the (R)-configuration of the piperazine ring is required for biological activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Process Chemistry & Scale-Up: Employed in the development and optimization of commercial-scale synthetic routes for API manufacturing under GMP guidelines.
• Agrochemical Development: Potential intermediate in the synthesis of chiral agrochemicals requiring specific stereochemistry for efficacy.

Basic Information

Product Name	(R)-1-Boc-2-Phenylpiperazine
CAS No.	886766-60-5
Molecular Formula	C15H22N2O2
Molecular Weight	262.35 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-2-phenylpiperazine; (R)-2-Phenyl-1-(tert-butoxycarbonyl)piperazine; (R)-N-Boc-2-phenylpiperazine; tert-Butyl (R)-2-phenylpiperazine-1-carboxylate; (R)-1-Boc-2-phenylpiperazine; (R)-Boc-Phenylpiperazine; (R)-2-Phenylpiperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (R)-1-Boc-2-Phenylpiperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity, chemical purity, and impurity profiles. Our quality commitment aligns with the standards expected by the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.