Description

3-(2,2,2-Trifluoro-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. Its value lies in the trifluoroethyl group, which imparts unique electronic and metabolic properties to target molecules, making it indispensable for medicinal chemistry research. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing novel active pharmaceutical ingredients (APIs), particularly in the areas of central nervous system (CNS) and oncology therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in CNS and oncology research pipelines.
• Medicinal Chemistry: Used to introduce the metabolically stable and lipophilic trifluoroethyl moiety into lead compounds to optimize pharmacokinetic properties.
• Peptidomimetics & Scaffold Development: Serves as a constrained scaffold or a building block for creating peptide-like molecules with enhanced bioavailability.
• Agrochemical Research: Employed in the synthesis of advanced intermediates for novel pesticides and herbicides, leveraging the fluorine atom's bioactivity.
• Ligand Synthesis for Catalysis: Used to prepare specialized piperazine-based ligands for asymmetric catalysis and metal complexation.
• Chemical Biology Probes: A valuable precursor for synthesizing molecular probes to study biological targets and pathways.

Basic Information

Product Name	3-(2,2,2-Trifluoro-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	886766-19-4
Molecular Formula	C11H19F3N2O2
Molecular Weight	268.28 g/mol
Synonyms	1-Boc-3-(2,2,2-trifluoroethyl)piperazine; tert-Butyl 3-(2,2,2-trifluoroethyl)piperazine-1-carboxylate; 3-(Trifluoroethyl)piperazine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-(2,2,2-trifluoroethyl)piperazine; N-Boc-3-(2,2,2-trifluoroethyl)piperazine; 886766-19-4; 3-(2,2,2-Trifluoroethyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-(2,2,2-Trifluoro-Ethyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your R&D and scale-up activities. We adhere to cGMP standards where applicable to ensure supply chain integrity for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.