Description

Ethyl 3-Nitro-4-Piperazin-1-Ylbenzoate is a specialized organic intermediate featuring a nitro-substituted benzoate ester linked to a piperazine moiety. This molecular architecture makes it a valuable building block for the synthesis of complex pharmacologically active compounds. It is primarily utilized by research institutions and pharmaceutical development companies engaged in medicinal chemistry and drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the development of compound libraries for high-throughput screening.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process development stages for creating new APIs that incorporate the piperazine pharmacophore.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	Ethyl 3-Nitro-4-Piperazin-1-Ylbenzoate
CAS No.	886631-29-4
Molecular Formula	C13H17N3O4
Molecular Weight	279.29 g/mol
Synonyms	Ethyl 3-nitro-4-(piperazin-1-yl)benzoate; 4-(Piperazin-1-yl)-3-nitrobenzoic acid ethyl ester; Benzoic acid, 3-nitro-4-(1-piperazinyl)-, ethyl ester; 886631-29-4; 3-Nitro-4-piperazin-1-yl-benzoic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 3-Nitro-4-Piperazin-1-Ylbenzoate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.