Description

2-(4-Boc-Piperazin-1-Yl-Methyl)Aniline is a key pharmaceutical intermediate featuring a protected piperazine moiety linked to an aniline group. This compound is essential for the synthesis of complex molecules, particularly in medicinal chemistry, where it serves as a versatile building block for introducing specific amine functionalities. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), especially within oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel drug candidates, particularly those targeting protein kinases and G-protein-coupled receptors (GPCRs).
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to modify the pharmacokinetic and pharmacodynamic properties of potential therapeutics.
• API Synthesis: Serves as a precursor in the manufacturing process of final Active Pharmaceutical Ingredients (APIs), enabling the incorporation of a functionalized piperazine-aniline scaffold.
• Protease Inhibitor Development: Applied in the research and development of protease inhibitors, where the aniline and protected amine groups are key pharmacophores.
• Chemical Biology Probes: Utilized in the creation of chemical probes and tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis organizations (CSOs) and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	2-(4-Boc-Piperazin-1-Yl-Methyl)Aniline
CAS No.	885278-02-4
Molecular Formula	C17H27N3O2
Molecular Weight	305.42 g/mol
Synonyms	1-Boc-4-[(2-Aminophenyl)methyl]piperazine; 2-[(4-tert-Butoxycarbonylpiperazin-1-yl)methyl]aniline; tert-Butyl 4-[(2-aminobenzyl)piperazine-1-carboxylate; 2-((4-(tert-Butoxycarbonyl)piperazin-1-yl)methyl)aniline; 2-(4-Boc-piperazin-1-ylmethyl)phenylamine; N-Boc-4-(2-aminobenzyl)piperazine; 885278-02-4; 2-(4-(tert-Butoxycarbonyl)piperazin-1-ylmethyl)aniline
EINECS	Contact for details

Quality Control

Our 2-(4-Boc-Piperazin-1-Yl-Methyl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.