Description

[4-(4-Chloro-Phenyl)-Piperazin-1-Yl]-Thiophen-2-Yl-Acetic Acid CAS NO 885276-92-6 is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular scaffold that combines piperazine and thiophene moieties. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and receptor-targeted therapeutic research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing new drug candidates.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates targeting neurological and psychiatric disorders.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: A crucial building block for constructing complex molecules with potential receptor (e.g., serotonin, dopamine) modulating activity.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and cGMP production of investigational new drugs.
• Biochemical Research: Employed as a tool compound in pharmacological assays to study specific biological pathways and protein interactions.
• Fine Chemical Production: Used in the multi-step synthesis of other specialized, high-value fine chemicals and advanced intermediates.

Basic Information

Product Name	[4-(4-Chloro-Phenyl)-Piperazin-1-Yl]-Thiophen-2-Yl-Acetic Acid
CAS No.	885276-92-6
Molecular Formula	C16H17ClN2O2S
Molecular Weight	336.84 g/mol
Synonyms	2-([4-(4-Chlorophenyl)piperazin-1-yl]thiophen-2-yl)acetic acid; 2-((4-(4-Chlorophenyl)piperazin-1-yl)thiophen-2-yl)acetic acid; 2-[4-(4-Chlorophenyl)piperazin-1-yl]thiophene-2-acetic acid; (2-{4-[(4-Chlorophenyl)piperazin-1-yl]}thiophen-2-yl)acetic acid; 4-(4-Chlorophenyl)-1-(2-carboxymethylthiophen-2-yl)piperazine; 885276-92-6; 2-[[4-(4-chlorophenyl)-1-piperazinyl]-2-thienyl]acetic acid
EINECS	Contact for details

Quality Control

Our [4-(4-Chloro-Phenyl)-Piperazin-1-Yl]-Thiophen-2-Yl-Acetic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.