Description

5-Phenyl-Piperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, protected piperidine-dicarboxylic acid derivative serving as a critical chiral building block and advanced pharmaceutical intermediate. This compound matters for its role in constructing complex molecular architectures, particularly in the synthesis of active pharmaceutical ingredients (APIs) and bioactive compounds. It is primarily needed by research institutions and pharmaceutical companies engaged in medicinal chemistry, process development, and the production of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing focused libraries and exploring structure-activity relationships (SAR) in drug discovery programs.
• Process Chemistry & Scale-up: Employed in the development and optimization of synthetic routes for the commercial manufacture of active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a starting material or intermediate in stereoselective synthesis due to its chiral piperidine core.
• Chemical Biology & Proteomics: Can serve as a component in the synthesis of chemical probes or ligands for target identification and validation.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-purity, complex heterocyclic intermediates.

Basic Information

Product Name	5-Phenyl-Piperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	885274-99-7
Molecular Formula	C17H23NO4
Molecular Weight	305.37 g/mol
Synonyms	1-(tert-Butyl) 3-methyl 5-phenylpiperidine-1,3-dicarboxylate; 5-Phenyl-1,3-piperidinedicarboxylic Acid 1-(1,1-Dimethylethyl) Ester; 1-tert-Butyl 5-phenylpiperidine-1,3-dicarboxylate; 5-Phenylpiperidine-1,3-dicarboxylic Acid 1-tert-Butyl Ester; tert-Butyl 5-phenyl-3-(methoxycarbonyl)piperidine-1-carboxylate; 1-Boc-5-phenyl-3-piperidinecarboxylic Acid Methyl Ester; 885274-99-7
EINECS	Contact for details

Quality Control

Our 5-Phenyl-Piperidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.