Description

4-[Carboxy-(3,4-Dichloro-Phenyl)-Methyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride is a high-purity, advanced pharmaceutical intermediate crucial for the synthesis of complex active pharmaceutical ingredients (APIs). Its value lies in its role as a key building block for constructing sophisticated piperazine-based molecular scaffolds, enabling the development of targeted therapeutics. This compound is essential for R&D and production teams in the pharmaceutical and biotechnology sectors, particularly those focused on developing new drugs in therapeutic areas requiring precise chemical modifications.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs), especially those targeting central nervous system (CNS) disorders.
• Protease Inhibitor Research: Serves as a key precursor in the development of protease inhibitors for antiviral and anticancer drug discovery programs.
• Kinase Inhibitor Synthesis: Used in constructing piperazine-containing scaffolds for potential kinase inhibitors, a major class of oncology and anti-inflammatory drugs.
• GPCR-Targeted Drug Development: Employed in the research and synthesis of compounds targeting G-protein-coupled receptors (GPCRs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.
• Academic & Institutional Research: Used in university and institutional laboratories for medicinal chemistry research and the study of structure-activity relationships (SAR).

Basic Information

Product Name	4-[Carboxy-(3,4-Dichloro-Phenyl)-Methyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride
CAS No.	885274-60-2
Molecular Formula	C18H25Cl2N2O4 • HCl
Molecular Weight	421.77 g/mol (Free base: 385.31 g/mol)
Synonyms	tert-Butyl 4-[(3,4-dichlorophenyl)(carboxy)methyl]piperazine-1-carboxylate hydrochloride; 1-Boc-4-[(3,4-dichlorophenyl)(carboxy)methyl]piperazine hydrochloride; 4-[(3,4-Dichlorophenyl)(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester hydrochloride (tautomer); 4-[(3,4-Dichlorobenzoyl)methyl]piperazine-1-carboxylic acid tert-butyl ester hydrochloride derivative; BOC-Piperazine-(3,4-dichlorophenyl)acetic acid hydrochloride; (3,4-Dichlorophenyl)(piperazin-1-yl)acetic acid tert-butyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and scale-up processes. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and Mass Spectrometry. A detailed Certificate of Analysis (COA) documenting purity, residual solvents, and specific impurities is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm
Assay (Titration)	97.0% - 103.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.