Description

2-(4-Boc-Piperazinyl)-2-(3-Trifluoromethyl-Phenyl)Acetic Acid is a high-value, protected piperazine derivative that serves as a critical building block in modern organic synthesis. Its core value lies in providing a versatile scaffold for constructing complex molecules, particularly in the pharmaceutical sector where the Boc-protected amine and trifluoromethylphenyl moiety are highly desirable. This compound is essential for medicinal chemists and process development scientists engaged in the research and synthesis of new active pharmaceutical ingredients (APIs), especially within therapeutic areas targeting the central nervous system and oncology.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those requiring a functionalized piperazine core.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Peptidomimetic Synthesis: Employed in the construction of peptide-like molecules where the acetic acid moiety can be used for further conjugation or cyclization.
• Ligand and Probe Development: Serves as a building block for creating specialized chemical probes and ligands for biological target identification and validation.
• Process Chemistry & Scale-up: Utilized in the development and optimization of scalable synthetic routes for advanced pharmaceutical intermediates.

Basic Information

Product Name	2-(4-Boc-Piperazinyl)-2-(3-Trifluoromethyl-Phenyl)Acetic Acid
CAS No.	885274-26-0
Molecular Formula	C18H23F3N2O4
Molecular Weight	388.38 g/mol
Synonyms	2-(4-Boc-Piperazin-1-yl)-2-[3-(trifluoromethyl)phenyl]acetic acid; 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-2-(3-(trifluoromethyl)phenyl)acetic acid; 1-Boc-4-(2-carboxy-2-(3-(trifluoromethyl)phenyl)ethyl)piperazine; 2-(3-Trifluoromethylphenyl)-2-(4-Boc-piperazinyl)acetic Acid; 2-(4-(tert-Butyloxycarbonyl)piperazinyl)-2-(3-trifluoromethylphenyl)acetic Acid; N-Boc-4-(2-carboxy-2-(3-trifluoromethylphenyl)ethyl)piperazine; (3-Trifluoromethylphenyl)(4-Boc-piperazinyl)acetic Acid
EINECS	Contact for details

Quality Control

Our 2-(4-Boc-Piperazinyl)-2-(3-Trifluoromethyl-Phenyl)Acetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, meeting the stringent requirements of pharmaceutical R&D and production. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support development with custom purity grades and analytical data packages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.