Description

2-(4-Boc-Piperazinyl)-2-(2-Trifluoromethyl-Phenyl)Acetic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine moiety and a trifluoromethylphenyl group. This compound is critical for medicinal chemists as a versatile building block in the synthesis of complex, biologically active molecules, particularly for drug discovery programs targeting central nervous system (CNS) disorders and other therapeutic areas. It is essential for research and development laboratories, contract manufacturing organizations (CMOs), and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel drug candidates, particularly those targeting neurological and psychiatric conditions.
• Protease Inhibitor Development: Used in research for constructing molecules that inhibit specific enzymes, such as those involved in viral replication or inflammatory pathways.
• Chemical Biology & Probe Synthesis: Serves as a precursor for creating molecular probes to study protein function and receptor interactions within biological systems.
• Peptidomimetic Chemistry: Integral for designing and synthesizing peptide-like compounds with enhanced metabolic stability and bioavailability.
• Library Synthesis for High-Throughput Screening (HTS): Employed to generate diverse compound libraries to identify new lead structures in drug discovery.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes for potential commercial APIs.

Basic Information

Product Name	2-(4-Boc-Piperazinyl)-2-(2-Trifluoromethyl-Phenyl)Acetic Acid
CAS No.	885274-23-7
Molecular Formula	C18H23F3N2O4
Molecular Weight	388.38 g/mol
Synonyms	2-(4-Boc-Piperazin-1-yl)-2-[2-(trifluoromethyl)phenyl]acetic Acid; 2-(2-(Trifluoromethyl)phenyl)-2-(4-(tert-butoxycarbonyl)piperazin-1-yl)acetic Acid; 1-Boc-4-[(2-(trifluoromethyl)phenyl)(carboxymethyl)]piperazine; 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-2-(2-(trifluoromethyl)phenyl)acetic Acid; (2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-2-(2-(trifluoromethyl)phenyl)acetic Acid; BOC-Pip-CF3-Ph-Gly-OH; tert-Butyl 4-(carboxy(2-(trifluoromethyl)phenyl)methyl)piperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 2-(4-Boc-Piperazinyl)-2-(2-Trifluoromethyl-Phenyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.