Description

2-(4-Boc-Piperazinyl)-2-(2-Nitro-Phenyl)Acetic Acid CAS NO 885274-14-6 is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine ring and a nitro-substituted phenylacetic acid core. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules with potential therapeutic activity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel drug candidates, particularly in the areas of central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of protease inhibitors and other enzyme-targeting therapeutics.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis and methodological development.

Basic Information

Product Name	2-(4-Boc-Piperazinyl)-2-(2-Nitro-Phenyl)Acetic Acid
CAS No.	885274-14-6
Molecular Formula	C₁₇H₂₃N₃O₆
Molecular Weight	365.38 g/mol
Synonyms	2-(4-Boc-Piperazinyl)-2-(2-Nitrophenyl)acetic Acid; 2-(2-Nitrophenyl)-2-[4-[(tert-butoxy)carbonyl]piperazin-1-yl]acetic Acid; 2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-2-(2-nitrophenyl)acetic Acid; 1-Boc-4-[(2-nitrobenzyl)carboxymethyl]piperazine; (2-Nitrophenyl)[4-(tert-butoxycarbonyl)piperazin-1-yl]acetic Acid; tert-Butyl 4-[carboxy(2-nitrophenyl)methyl]piperazine-1-carboxylate; Boc-Pip(2-NO₂-Ph)-OH; 885274-14-6
EINECS	Contact for details

Quality Control

Our 2-(4-Boc-Piperazinyl)-2-(2-Nitro-Phenyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.