Description

4-[Carboxy-(3-Chloro-Phenyl)-Methyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a defined molecular structure, essential for precise chemical synthesis. This compound is critical for research and development in medicinal chemistry, serving as a key building block for the creation of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and fine chemical synthesis specialists requiring a reliable and consistent source of this specific piperazine derivative.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• API (Active Pharmaceutical Ingredient) Development: Used in research and process development for creating new therapeutic molecules with piperazine-based pharmacophores.
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) in drug discovery programs for various disease targets.
• Custom Synthesis & Scale-Up: Serves as a starting material for contract manufacturing organizations (CMOs) specializing in custom synthesis from gram to kilogram scale.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in pharmaceutical laboratories.

Basic Information

Product Name	4-[Carboxy-(3-Chloro-Phenyl)-Methyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride
CAS No.	885272-99-1
Molecular Formula	C18H25ClN2O4 • HCl
Molecular Weight	397.32 g/mol (for free base: 360.86 g/mol)
Synonyms	tert-Butyl 4-[(3-chlorophenyl)(carboxy)methyl]piperazine-1-carboxylate hydrochloride; 1-Boc-4-[(3-chlorophenyl)(carboxy)methyl]piperazine hydrochloride; 4-[(3-Chlorophenyl)(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester hydrochloride (tautomeric form); (3-Chlorophenyl)(4-(tert-butoxycarbonyl)piperazin-1-yl)acetic acid hydrochloride; BOC-Piperazine-(3-chlorophenyl)acetic acid hydrochloride; 885272-99-1; 4-[(3-Chlorobenzoyl)methyl]-1-Boc-piperazine hydrochloride (related precursor).
EINECS	Contact for details

Quality Control

Our 4-[Carboxy-(3-Chloro-Phenyl)-Methyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing all specification results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.