Description

2-(4-Boc-Piperazinyl)-2-(3-Fluoro-Phenyl)Acetic Acid is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex molecules, particularly for active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily utilized by research institutions, contract research/manufacturing organizations (CROs/CMOs), and pharmaceutical companies engaged in the development of novel small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, especially in medicinal chemistry programs.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs), leveraging its protected piperazine and fluorinated phenyl motifs.
• CNS Drug Research: Particularly valuable in the research and development of central nervous system (CNS) targeting therapeutics due to its structural features.
• Peptidomimetic Chemistry: Serves as a precursor for creating peptidomimetics and other bioisosteres in drug design.
• Library Synthesis: Employed in combinatorial and parallel synthesis to create diverse chemical libraries for high-throughput screening.
• Process Chemistry & Scale-Up: Used in process research and development (PR&D) for optimizing synthetic routes from lab to pilot and commercial scale.

Basic Information

Product Name	2-(4-Boc-Piperazinyl)-2-(3-Fluoro-Phenyl)Acetic Acid
CAS No.	885272-91-3
Molecular Formula	C₁₇H₂₃FN₂O₄
Molecular Weight	338.38 g/mol
Synonyms	2-(4-(tert-Butoxycarbonyl)piperazin-1-yl)-2-(3-fluorophenyl)acetic acid; 2-(3-Fluorophenyl)-2-[4-[(2-methylpropan-2-yl)oxycarbonyl]piperazin-1-yl]acetic acid; 2-(4-Boc-Piperazino)-2-(3-Fluorophenyl)Acetic Acid; N-Boc-3-fluoro-α-(piperazin-1-yl)phenylacetic acid; (3-Fluorophenyl)[4-[(1,1-dimethylethoxy)carbonyl]-1-piperazinyl]acetic acid; tert-Butyl 4-[(3-fluorophenyl)(carboxymethyl)amino]piperidine-1-carboxylate (tautomeric form); Boc-Pip(3-F-Ph)-OH (common abbreviation).
EINECS	Contact for details

Quality Control

Our 2-(4-Boc-Piperazinyl)-2-(3-Fluoro-Phenyl)Acetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are available for every lot to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled and stored away from direct light exposure. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.