Description

1-n-Cbz-3-Cyanopiperidine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Protease Inhibitor Synthesis: Serves as a precursor in the development of protease inhibitors due to its piperidine-3-carbonitrile core.
• CNS Drug Development: Employed in the research of compounds targeting neurological disorders and pain management.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific molecules.

Basic Information

Product Name	1-n-Cbz-3-Cyanopiperidine
CAS No.	885069-22-7
Molecular Formula	C14H16N2O2
Molecular Weight	244.29 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-cyanopiperidine; 1-Carbobenzoxy-3-cyanopiperidine; 3-Cyano-1-[(phenylmethoxy)carbonyl]piperidine; 1-Cbz-3-cyanopiperidine; 1-N-Carbobenzyloxy-3-cyanopiperidine; Benzyl 3-cyano-1-piperidinecarboxylate; 3-Cyano-N-Cbz-piperidine; Piperidine-3-carbonitrile, 1-[(phenylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our 1-n-Cbz-3-Cyanopiperidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR. We adhere to cGMP principles where applicable to support our clients' regulatory and quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.