Description

1-Palmitoyl-3-Oleoyl-Sn-Glycero-2-Phosphoethanolamine (1,3-POPE) is a high-purity, synthetic phospholipid with a defined fatty acid composition, serving as a critical building block for advanced lipid-based research and formulations. This compound is essential for creating biomimetic membrane models and enhancing the stability and delivery efficiency of lipid nanoparticles. It is primarily needed by researchers and developers in the pharmaceutical, biotechnology, and advanced material science sectors for applications in drug delivery systems, membrane biophysics studies, and the development of liposomal therapeutics.

Application

• Lipid Nanoparticle (LNP) Formulation: A key structural component for constructing stable, non-viral delivery vectors for mRNA, siRNA, and other nucleic acid therapeutics.
• Liposome & Vesicle Preparation: Used to create unilamellar or multilamellar vesicles with specific membrane fluidity and phase behavior for drug encapsulation and controlled release studies.
• Biomimetic Membrane Models: Essential for constructing supported lipid bilayers (SLBs) and giant unilamellar vesicles (GUVs) to study cell membrane mechanics, protein-lipid interactions, and signaling pathways.
• Drug Delivery Research: Incorporated into liposomal formulations to improve the pharmacokinetic profile, targeting, and cellular uptake of encapsulated small molecule drugs.
• Cell Culture & Transfection Reagents: A component in specialized lipid mixtures used to enhance the efficiency of in vitro transfection protocols.
• Analytical Standards & Reference Materials: Serves as a high-purity standard for lipidomics research, mass spectrometry calibration, and quality control in lipid manufacturing.

Basic Information

Product Name	1-Palmitoyl-3-Oleoyl-Sn-Glycero-2-Phosphoethanolamine (1,3-POPE)
CAS No.	884324-34-9
Molecular Formula	C39H76NO8P
Molecular Weight	718.00 g/mol
Synonyms	1,3-POPE; POPE (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine, positional isomer); 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (structural isomer); 1-Palmitoyl-3-oleoyl-sn-glycero-2-phosphorylethanolamine; (2R)-2-Hydroxy-3-[(9Z)-octadec-9-enoyloxy]propyl (2-{[hexadecanoyloxy]methyl}(hydroxy)phosphoryl)ethylazanide; Phosphatidylethanolamine (16:0/18:1(9Z)); PE(16:0/18:1); 1,3-Diacyl-sn-glycero-2-phosphoethanolamine
EINECS	Contact for details

Quality Control

Our 1,3-POPE is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research and formulation work. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and critical impurity profiles. We adhere to relevant industry guidelines for lipid synthesis and can provide material traceability documentation upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). This product is hygroscopic (moisture-sensitive) and easily oxidized; allow the sealed vial to equilibrate to room temperature before opening to minimize condensation. Once opened, purge the container with inert gas and reseal immediately.

Specification

Item	Specification
Appearance	White to off-white powder or waxy solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
1-Palmitoyl-3-Oleoyl Isomer Purity	≥ 95.0%
Loss on Drying	≤ 2.0 %
Heavy Metals (as Pb)	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.