Description

4-(3-Amino-Benzoyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, protected piperazine derivative and a crucial synthetic intermediate in modern organic chemistry. Its value lies in its bifunctional structure, featuring both a reactive amino group and a tert-butyloxycarbonyl (Boc)-protected secondary amine, enabling selective and sequential synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules and active pharmaceutical ingredients (APIs) through targeted amide bond formation and further functionalization.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in the development of kinase inhibitors, receptor antagonists, and other small-molecule therapeutics.
• Agrochemical Research: Used in creating advanced pesticide and herbicide molecules where the piperazine scaffold contributes to biological activity.
• Peptidomimetics & PROTACs: Serves as a versatile linker or core component in the design of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) for targeted protein degradation.
• Chemical Biology Probes: Employed in the development of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Material Science: Potential monomer or cross-linking agent in the synthesis of specialized polymers with unique thermal or mechanical properties.

Basic Information

Product Name	4-(3-Amino-Benzoyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	883554-97-0
Molecular Formula	C16H23N3O3
Molecular Weight	305.38 g/mol
Synonyms	1-Boc-4-(3-aminobenzoyl)piperazine; tert-Butyl 4-(3-aminobenzoyl)piperazine-1-carboxylate; 4-(3-Aminobenzoyl)piperazine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(3-aminobenzoyl)piperazine; N-Boc-4-(3-aminobenzoyl)piperazine; Piperazine, 4-(3-aminobenzoyl)-, 1-(1,1-dimethylethyl) ester; 883554-97-0; 4-(3-Amino-benzoyl)-piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch of 4-(3-Amino-Benzoyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is analyzed using advanced techniques like HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. We adhere to strict in-process controls, and comprehensive Certificates of Analysis (COA) detailing all specifications are available upon request. Our quality management system supports the needs of research and cGMP-grade manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.