Description

tert-Butyl 4-Carbamoylpiperazine-1-Carboxylate is a high-purity, protected piperazine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile, reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Scaffold: Used extensively in lead optimization and structure-activity relationship (SAR) studies due to its modifiable carbamoyl and protected amine functionalities.
• Peptidomimetic Synthesis: Serves as a constrained dipeptide isostere or a building block for creating novel peptide-like compounds with enhanced metabolic stability.
• Library Synthesis for Drug Discovery: Employed in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.
• Agrochemical Research: Utilized as an intermediate in the development of new herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Acts as a precursor for synthesizing specialized ligands used in asymmetric catalysis and metal complexation.

Basic Information

Product Name	tert-Butyl 4-Carbamoylpiperazine-1-Carboxylate
CAS No.	883554-88-9
Molecular Formula	C10H19N3O3
Molecular Weight	229.28 g/mol
Synonyms	1-Boc-4-carbamoylpiperazine; 1-(tert-Butoxycarbonyl)-4-carbamoylpiperazine; 4-Carbamoylpiperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-aminocarbonylpiperazine-1-carboxylate; N-Boc-4-piperazinecarboxamide; Piperazine-1-carboxamide, 4-(1,1-dimethylethoxy)carbonyl]-; BOC-Piperazine-4-carboxamide
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Carbamoylpiperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.