Description

(1-Cbz-Piperidin-4-Yl-Azetidin-3-Yl)-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate designed for complex organic synthesis. This compound is critical for medicinal chemistry research and development, serving as a key building block in the creation of novel active pharmaceutical ingredients (APIs). It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on developing new therapeutic agents, particularly in the areas of central nervous system (CNS) and metabolic disease treatments.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel drug candidates, particularly those targeting protease and kinase enzymes.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new pharmacophores with improved efficacy and selectivity.
• Peptidomimetic Synthesis: Serves as a core scaffold for constructing peptidomimetics and constrained peptides, which are important in developing metabolically stable therapeutic agents.
• API Development: Integral to the research and scale-up processes for new Active Pharmaceutical Ingredients (APIs) in pre-clinical and clinical development phases.
• Chemical Biology Probes: Employed in the synthesis of chemical probes for studying biological pathways and target validation in disease models.
• Custom Synthesis: Provided to CROs and CDMOs for bespoke synthesis projects requiring high-purity, complex heterocyclic intermediates.

Basic Information

Product Name	(1-Cbz-Piperidin-4-Yl-Azetidin-3-Yl)-Carbamic Acid tert-Butyl Ester
CAS No.	883546-87-0
Molecular Formula	C22H33N3O4
Molecular Weight	403.52 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-4-(3-{[(tert-butoxy)carbonyl]amino}azetidin-1-yl)piperidine; tert-Butyl N-[1-[1-[(benzyloxy)carbonyl]piperidin-4-yl]azetidin-3-yl]carbamate; 1-Cbz-4-(3-Boc-aminoazetidin-1-yl)piperidine; Boc-Azetidine-Piperidine-Cbz; (1-Cbz-Piperidin-4-yl-Azetidin-3-yl)-Carbamic Acid tert-Butyl Ester; N-Boc-3-amino-1-(1-Cbz-piperidin-4-yl)azetidine; 883546-87-0
EINECS	Contact for details

Quality Control

Our (1-Cbz-Piperidin-4-Yl-Azetidin-3-Yl)-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material is suitable for advanced research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.