Description

4-(3-Amino-Phenylcarbamoyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting neurological and oncological pathways. It is primarily utilized by research institutions, custom synthesis firms, and large-scale pharmaceutical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly in medicinal chemistry research and development.
• API Synthesis: Used as a building block for constructing active pharmaceutical ingredients (APIs) with piperidine and aniline pharmacophores.
• Protease Inhibitor Development: Employed in the research and production of protease inhibitors due to its carbamoyl-piperidine structure.
• Kinase Inhibitor Scaffold: Serves as a core scaffold or side-chain component in the development of novel kinase inhibitors for oncology.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Chemical Reference Standard: Used as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	4-(3-Amino-Phenylcarbamoyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	883106-64-7
Molecular Formula	C17H25N3O3
Molecular Weight	319.40 g/mol
Synonyms	1-Boc-4-[(3-aminophenyl)carbamoyl]piperidine; tert-Butyl 4-[(3-aminophenyl)carbamoyl]piperidine-1-carboxylate; 4-(3-Aminobenzamido)piperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-[(3-aminophenyl)carbamoyl]piperidine; N-(3-Aminophenyl)-1-Boc-4-piperidinecarboxamide; 883106-64-7; BOC-PIP-4-CONH-(3-NH2-Ph)
EINECS	Contact for details

Quality Control

Our production of 4-(3-Amino-Phenylcarbamoyl)-Piperidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.