Description

4-[2-Amino-4-(Trifluoromethyl)Phenyl]-2-Piperazinone is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethylphenyl-piperazinone structure. This compound is of significant commercial value for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new drug candidates, especially those targeting neurological disorders.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex APIs, leveraging its amino and piperazinone functional groups for further derivatization.
• Medicinal Chemistry Research: Serves as a crucial scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Preclinical Development: Supplied in development quantities for process optimization, scale-up studies, and the production of non-GMP batches for early-stage testing.
• Chemical Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical manufacturing.

Basic Information

Product Name	4-[2-Amino-4-(Trifluoromethyl)Phenyl]-2-Piperazinone
CAS No.	882672-41-5
Molecular Formula	C11H12F3N3O
Molecular Weight	259.23 g/mol
Synonyms	2-Piperazinone, 4-[2-amino-4-(trifluoromethyl)phenyl]-; 4-(2-Amino-4-trifluoromethylphenyl)-2-piperazinone; 4-(2-Amino-4-(trifluoromethyl)phenyl)piperazin-2-one; 882672-41-5; 4-(2-Amino-4-trifluoromethyl-phenyl)-2-piperazinone; 4-(2-Amino-4-(trifluoromethyl)phenyl)-2-piperazinone
EINECS	Contact for details

Quality Control

Our 4-[2-Amino-4-(Trifluoromethyl)Phenyl]-2-Piperazinone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.