Description

2,4-Dinitrophenylhydrazine-13C6 is a stable isotope-labeled derivative of the classic carbonyl derivatization reagent, 2,4-dinitrophenylhydrazine (DNPH). This compound is critical for providing unmatched accuracy and reliability in quantitative mass spectrometry analysis, where it serves as an internal standard to correct for analyte loss and instrument variability. It is an essential tool for analytical chemists and researchers in pharmaceutical development, environmental monitoring, and food safety testing who require precise quantification of aldehydes and ketones.

Application

• Quantitative LC-MS/MS Analysis: Used as a stable isotope-labeled internal standard for the precise quantification of carbonyl compounds (aldehydes, ketones) in complex matrices.
• Pharmaceutical Impurity Profiling: Essential for tracking and quantifying genotoxic impurities (GTIs) like aldehydes in active pharmaceutical ingredients (APIs) and drug products under ICH Q3 guidelines.
• Environmental Air Monitoring: Critical for the accurate measurement of formaldehyde and other volatile organic carbonyls in indoor and outdoor air samples.
• Food and Beverage Safety: Enables reliable detection of off-flavors, spoilage markers, and process contaminants like Strecker aldehydes.
• Metabolomics and Biomarker Discovery: Facilitates the accurate measurement of carbonyl-containing metabolites in biological fluids for disease research.
• Material Degradation Studies: Used to analyze carbonyl compounds released from polymers, coatings, and other materials during stability testing.

Basic Information

Product Name	2,4-Dinitrophenylhydrazine-13C6
CAS No.	882513-61-3
Molecular Formula	13C6H6N4O4
Molecular Weight	~200.10 g/mol (exact mass varies with isotopic enrichment)
Synonyms	DNPH-13C6; 2,4-DNPH-13C6; (2,4-Dinitrophenyl)hydrazine-13C6; Carbon-13 Labeled DNPH; Isotopically Labeled 2,4-Dinitrophenylhydrazine; 13C6-2,4-Dinitrophenylhydrazine; Stable Isotope Internal Standard DNPH
EINECS	Contact for details

Quality Control

Every batch of 2,4-Dinitrophenylhydrazine-13C6 is manufactured and tested to meet the stringent requirements for stable isotope-labeled analytical standards. Our quality assurance includes verification of isotopic purity (atom % 13C), chemical purity (by HPLC), and structural identity (by NMR and MS). Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results to ensure traceability and compliance with GMP and ISO 9001 principles for reliable integration into regulated laboratory workflows.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to minimize oxidation. The container should be kept in a cool, dry, and well-ventilated place. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Orange to red crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (Atom % 13C)	≥99%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.