Description

Piperidin-4-Yl-(2-Trifluoromethyl-Phenyl)-Methanone Hydrochloride is a high-purity, non-racemic chiral building block of significant interest in advanced pharmaceutical research and development. This compound matters as a sophisticated intermediate for constructing complex molecules, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily needed by medicinal chemists and process development scientists in pharmaceutical, biotechnology, and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for CNS-targeted therapies.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its piperidine scaffold and trifluoromethylphenyl moiety.
• Process Chemistry: Serves as a critical building block in the scale-up and route development for potential Active Pharmaceutical Ingredients (APIs).
• Chemical Biology: Employed as a probe or ligand in the study of biological targets and receptor interactions.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value fine chemicals and advanced intermediates.

Basic Information

Item	Detail
Product Name	Piperidin-4-Yl-(2-Trifluoromethyl-Phenyl)-Methanone Hydrochloride
CAS No.	881391-41-9
Molecular Formula	C13H14F3NO·HCl
Molecular Weight	293.71 g/mol (Free base: 257.25 g/mol)
Synonyms	4-(2-Trifluoromethylbenzoyl)piperidine hydrochloride; (2-Trifluoromethylphenyl)(4-piperidinyl)methanone hydrochloride; 1-(2-Trifluoromethylbenzoyl)piperidin-4-one hydrochloride (tautomer); 4-Piperidinyl 2-(trifluoromethyl)phenyl ketone hydrochloride; Ketone, (2-trifluoromethylphenyl)(4-piperidinyl)-, hydrochloride; 881391-41-9; (4-Piperidyl)-(2-trifluoromethyl-phenyl)-methanone hydrochloride
EINECS	Contact for details

Quality Control

Our Piperidin-4-Yl-(2-Trifluoromethyl-Phenyl)-Methanone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.