Description

5-Chloro-2-[4-(Trifluoroacetyl)Piperazin-1-Yl]Aniline is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoroacetyl-piperazine-aniline scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting central nervous system and other therapeutic areas. It is primarily utilized by pharmaceutical R&D laboratories, custom synthesis providers, and agrochemical innovators seeking to incorporate its specific halogenated and fluorinated motifs into new molecular entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in neurological and psychiatric disorder research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its piperazine and aniline functional groups.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material or intermediate for custom API synthesis under GMP or non-GMP conditions.
• Agrochemical Development: Potential intermediate in the research and synthesis of new generation pesticides and herbicides.
• Chemical Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.
• Academic & Institutional Research: Employed in universities and research institutes for exploratory organic synthesis and new reaction methodology development.

Basic Information

Product Name	5-Chloro-2-[4-(Trifluoroacetyl)Piperazin-1-Yl]Aniline
CAS No.	879590-39-3
Molecular Formula	C12H11ClF3N3O
Molecular Weight	305.68 g/mol
Synonyms	1-(4-Amino-2-chlorophenyl)-4-(trifluoroacetyl)piperazine; 2-Chloro-5-[4-(trifluoroacetyl)-1-piperazinyl]aniline; 5-Chloro-2-(4-trifluoroacetylpiperazin-1-yl)aniline; 879590-39-3; 5-Chloro-2-[4-(trifluoroacetyl)-1-piperazinyl]benzenamine; N-(4-Amino-2-chlorophenyl)-N'-(trifluoroacetyl)piperazine; 2-Amino-4-chloro-N-(2,2,2-trifluoroacetyl)piperazin-1-ylbenzene
EINECS	Contact for details

Quality Control

Our 5-Chloro-2-[4-(Trifluoroacetyl)Piperazin-1-Yl]Aniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided with every shipment. We support development and commercial projects with material suitable for research use, and can discuss scalable synthesis under controlled conditions for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.