Description

4-(Chloroacetyl)Piperazin-1-Yl](4-Fluorophenyl)Acetonitrile is a high-purity, advanced pharmaceutical intermediate characterized by its unique piperazine-acetonitrile core structure. This compound matters for its critical role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and oncological pathways. Pharmaceutical R&D and manufacturing companies need this precise building block to develop new drug candidates and ensure scalable, reproducible production processes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drugs, particularly for neurological and psychiatric disorders.
• API Synthesis: Used in multi-step synthetic routes to construct complex active pharmaceutical ingredients (APIs) with piperazine-based pharmacophores.
• Medicinal Chemistry Research: Serves as a versatile scaffold in drug discovery for creating focused libraries and optimizing lead compounds.
• Preclinical Development: Enables the production of gram to kilogram quantities of candidate molecules for pharmacological and toxicological studies.
• Chemical Biology Probes: Utilized in the development of tool compounds for studying biological targets and pathways.

Basic Information

Product Name	4-(Chloroacetyl)Piperazin-1-Yl](4-Fluorophenyl)Acetonitrile
CAS No.	877825-68-8
Molecular Formula	C14H15ClFN3O
Molecular Weight	295.74 g/mol
Synonyms	4-(Chloroacetyl)-1-[(4-fluorophenyl)(cyano)methyl]piperazine; 1-[(4-Fluorophenyl)(cyano)methyl]-4-(2-chloroacetyl)piperazine; (4-Fluorophenyl)(4-(2-chloroacetyl)piperazin-1-yl)acetonitrile; 877825-68-8; 4-Fluorophenyl[4-(chloroacetyl)-1-piperazinyl]acetonitrile; 4-(Chloroacetyl)-N-[(4-fluorophenyl)(cyano)methyl]piperazine; Acetonitrile, (4-fluorophenyl)[4-(2-chloroacetyl)-1-piperazinyl]-
EINECS	Contact for details

Quality Control

Our 4-(Chloroacetyl)Piperazin-1-Yl](4-Fluorophenyl)Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific customer or regulatory requirements, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.