Description

(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-n-(2-Hydroxyethyl)Icosa-6,8,10,14-Tetraenamide is a high-purity, synthetic lipoxin analog with a defined stereochemistry. This compound matters for its role as a potent, stable mediator in the resolution of inflammation, offering significant research and development potential. It is primarily needed by pharmaceutical R&D teams, biochemical researchers, and advanced material scientists working on novel anti-inflammatory therapeutics, signaling pathway studies, and specialized fine chemical synthesis. CAS No. 877459-63-7 identifies this specific stereoisomer.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anti-inflammatory and pro-resolving drugs.
• Biochemical Pathway Analysis: Used in cell culture and in vitro studies to investigate lipoxin-mediated signaling pathways and mechanisms of inflammation resolution.
• Reference Standard for Analytical Testing: Serves as a high-purity certified standard for HPLC, LC-MS, and NMR methods in quality control and metabolic studies.
• Preclinical Studies: Employed in animal models to evaluate the efficacy and pharmacokinetics of lipoxin-based therapeutic candidates.
• Specialty Chemical Synthesis: Acts as a sophisticated building block for the synthesis of more complex bioactive molecules and labeled analogs (e.g., deuterated, fluorescent).
• Academic Research: Utilized in universities and research institutes for fundamental studies in immunology, biochemistry, and medicinal chemistry.

Basic Information

Product Name	(5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-n-(2-Hydroxyethyl)Icosa-6,8,10,14-Tetraenamide
CAS No.	877459-63-7
Molecular Formula	C22H39NO4
Molecular Weight	381.56 g/mol
Synonyms	15-epi-16-(para-fluorophenoxy)-lipoxin A4 methyl ester analog; Lipoxin A4 stable analog; 5(S),6(R),15(R)-Trihydroxy-7,9,13-trans-11-cis-eicosatetraenoic acid derivative; N-(2-Hydroxyethyl)-5,12-dihydroxyicosa-6,8,10,14-tetraenamide; LXA4 analog; Anti-inflammatory mediator analog; Resolution-phase mediator; Eicosanoid derivative
EINECS	Contact for details

Quality Control

Our (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxy-n-(2-Hydroxyethyl)Icosa-6,8,10,14-Tetraenamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry for identity verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.