Description

cis-3,5-Piperidinedicarboxylic Acid is a high-purity, versatile dicarboxylic acid derivative of piperidine, serving as a critical chiral building block and intermediate in advanced organic synthesis. Its rigid, bicyclic structure and dual carboxylic acid functionality make it invaluable for constructing complex molecular architectures with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries, particularly for applications requiring constrained peptidomimetics, chiral ligands, and active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of novel drug candidates, especially in central nervous system (CNS) and metabolic disease research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides with specific stereochemical activity.
• Chiral Ligand & Catalyst Precursor: Serves as a starting material for synthesizing sophisticated ligands used in asymmetric catalysis.
• Peptidomimetics & Constrained Amino Acids: Integral for designing and synthesizing conformationally restricted peptide analogs to improve metabolic stability and bioavailability.
• Specialty Polymer Monomer: Potential use in creating novel polyamides and polyesters with unique thermal and mechanical properties.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	cis-3,5-Piperidinedicarboxylic Acid
CAS No.	876367-84-9
Molecular Formula	C7H11NO4
Molecular Weight	173.17 g/mol
Synonyms	3,5-Piperidinedicarboxylic acid, cis-; (3R,5S)-3,5-Piperidinedicarboxylic acid; (3S,5R)-3,5-Piperidinedicarboxylic acid; cis-Hexahydroisophthalic acid; 1-Azabicyclo[3.3.0]octane-3,5-dicarboxylic acid; Piperidine-3,5-dicarboxylic acid (cis-isomer); NSC 760443
EINECS	Contact for details

Quality Control

Our cis-3,5-Piperidinedicarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformity to customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.