Description

1-Boc-4-[2-(1H-Indol-3-Yl)-Ethyl]-Piperazine is a high-purity, protected piperazine derivative of significant importance in modern pharmaceutical research and development. This compound serves as a versatile and critical building block for the synthesis of complex molecules, particularly those targeting central nervous system (CNS) disorders. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery of new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, especially for neurological and psychiatric applications.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization processes due to its modifiable piperazine and indole moieties.
• API Synthesis: Employed in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) that incorporate a substituted piperazine core.
• Bioconjugation & Probe Development: The Boc-protected amine allows for selective deprotection, making it useful for creating labeled compounds or molecular probes for biological studies.
• Academic Research: Serves as a standard reagent in university and institutional labs for organic synthesis and methodological development.

Basic Information

Product Name	1-Boc-4-[2-(1H-Indol-3-Yl)-Ethyl]-Piperazine
CAS No.	875900-94-0
Molecular Formula	C19H27N3O2
Molecular Weight	329.44 g/mol
Synonyms	1-Boc-4-(2-(1H-Indol-3-yl)ethyl)piperazine; tert-Butyl 4-[2-(1H-indol-3-yl)ethyl]piperazine-1-carboxylate; 4-(2-Indol-3-ylethyl)-1-piperazinecarboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-[2-(1H-indol-3-yl)ethyl]piperazine; N-Boc-4-(2-(1H-indol-3-yl)ethyl)piperazine; Piperazine, 1-(1,1-dimethylethoxy)carbonyl-4-[2-(1H-indol-3-yl)ethyl]-; BOC-Piperazine-Indole Derivative
EINECS	Contact for details

Quality Control

Our 1-Boc-4-[2-(1H-Indol-3-Yl)-Ethyl]-Piperazine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and mass spectrometry. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.