Description

3-Amino-6-Iodopyrazine-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a reactive carboxylic acid group, a versatile amino group, and an iodine substituent on a pyrazine core, enabling precise derivatization and cross-coupling reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly kinase inhibitors and other targeted therapeutics.
• Agrochemical Research: Used to develop novel active ingredients for crop protection with specific modes of action.
• Material Science Building Block: Employed in the creation of organic electronic materials, ligands for catalysis, and specialty polymers.
• Cross-Coupling Reactions: The iodine atom serves as an excellent handle for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Peptidomimetics & Bio-conjugation: The carboxylic acid and amino groups facilitate its incorporation into peptide-like structures or linkage to biomolecules.
• Chemical Library Synthesis: A versatile scaffold for generating diverse compound libraries in medicinal chemistry for high-throughput screening.

Basic Information

Product Name	3-Amino-6-Iodopyrazine-2-Carboxylic Acid
CAS No.	875781-48-9
Molecular Formula	C5H4IN3O2
Molecular Weight	264.99 g/mol
Synonyms	6-Iodo-3-aminopyrazine-2-carboxylic acid; 3-Amino-6-iodo-2-pyrazinecarboxylic acid; 2-Pyrazinecarboxylic acid, 3-amino-6-iodo-; AI3-52044; ZINC000103048758; AKOS025310947; BDBM50389335; CTK8G7235
EINECS	Contact for details

Quality Control

Every batch of 3-Amino-6-Iodopyrazine-2-Carboxylic Acid is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical research and development projects. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) is supplied with each shipment, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.