Description

5-Bromo-3-((trimethylsilyl)ethynyl)pyrazin-2-amine is a high-value, functionalized pyrazine derivative featuring both a bromo and a trimethylsilyl-protected ethynyl group. This unique bifunctional structure makes it a critical advanced pharmaceutical intermediate (API) and a versatile building block for constructing complex molecular architectures. It is primarily sought after by R&D and process chemistry teams in the pharmaceutical, agrochemical, and advanced materials sectors for applications in drug discovery, cross-coupling reactions, and the synthesis of novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a building block for organic electronic materials, such as organic semiconductors and light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromo substituent is an excellent site for Suzuki, Sonogashira, and Buchwald-Hartwig cross-coupling reactions to create complex biaryl and conjugated systems.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological processes due to its modifiable functional groups.
• Academic & Industrial R&D: A valuable reagent for synthetic organic chemists exploring new reaction methodologies and heterocyclic chemistry.

Basic Information

Item	Detail
Product Name	5-Bromo-3-((trimethylsilyl)ethynyl)pyrazin-2-amine
CAS No.	875781-41-2
Molecular Formula	C9H14BrN3Si
Molecular Weight	272.22 g/mol
Synonyms	2-Amino-5-bromo-3-[(trimethylsilyl)ethynyl]pyrazine; 5-Bromo-3-((trimethylsilyl)ethynyl)-2-pyrazinamine; 5-Bromo-3-ethynyl-2-pyrazinamine, trimethylsilyl ether; 875781-41-2; 5-Bromo-3-(2-trimethylsilylethynyl)pyrazin-2-ylamine
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-3-((trimethylsilyl)ethynyl)pyrazin-2-amine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our standard grade meets high-purity requirements suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC/NMR), identity confirmation, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.