Description

1-(2,6-Difluorobenzyl)Piperazine is a high-purity, specialized organic building block featuring a piperazine ring substituted with a 2,6-difluorobenzyl group. This compound is valued for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where its unique fluorine-substituted aromatic structure imparts desirable biological activity and metabolic stability. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for developing new active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluorobenzyl moiety enhances efficacy and environmental profile.
• Ligand & Catalyst Preparation: Serves as a precursor for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Fine Chemical Building Block: Employed in custom synthesis and contract manufacturing for producing complex, high-value specialty chemicals.
• Biochemical Research: Utilized as a reference standard or reagent in life science research for studying enzyme inhibition and receptor binding.
• Material Science: Potential monomer or additive in the synthesis of advanced polymers with specific thermal or chemical resistance properties.

Basic Information

Product Name	1-(2,6-Difluorobenzyl)Piperazine
CAS No.	874774-61-5
Molecular Formula	C11H14F2N2
Molecular Weight	212.24 g/mol
Synonyms	1-[(2,6-Difluorophenyl)methyl]piperazine; 2,6-Difluorobenzylpiperazine; Piperazine, 1-[(2,6-difluorophenyl)methyl]-; 874774-61-5; 1-(2,6-Difluorobenzyl)piperazine; (2,6-Difluorobenzyl)piperazine; N-(2,6-Difluorobenzyl)piperazine
EINECS	Contact for details

Quality Control

Our 1-(2,6-Difluorobenzyl)Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.