Description

3-(4-Boc-Piperazin-1-Yl-Methyl)-5-Fluoroaniline is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine ring and an aniline moiety. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing complex molecules. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas. Its defined structure enables precise molecular modifications essential for drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of potential drug candidates, especially kinase inhibitors and receptor modulators.
• Proteolysis Targeting Chimera (PROTAC) Development: Used as a linker or warhead component in the design of targeted protein degradation therapeutics.
• Chemical Biology & Probe Synthesis: Employed in creating molecular probes for studying enzyme function and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of non-commercial, research-scale quantities of specialized compounds.
• Academic Research: Used in university and institutional labs for fundamental research in organic synthesis and medicinal chemistry.

Basic Information

Product Name	3-(4-Boc-Piperazin-1-Yl-Methyl)-5-Fluoroaniline
CAS No.	873697-59-7
Molecular Formula	C17H26FN3O2
Molecular Weight	323.41 g/mol
Synonyms	1-Boc-4-[(3-Amino-5-fluorophenyl)methyl]piperazine; tert-Butyl 4-[(3-amino-5-fluorophenyl)methyl]piperazine-1-carboxylate; 5-Fluoro-3-[(4-(tert-butoxycarbonyl)piperazin-1-yl)methyl]aniline; 3-[(4-Boc-piperazin-1-yl)methyl]-5-fluoroaniline; 5-Fluoro-3-(1-Boc-piperazin-4-ylmethyl)aniline; 873697-59-7; BOC-Piperazine-F-aniline intermediate
EINECS	Contact for details

Quality Control

Every batch of 3-(4-Boc-Piperazin-1-Yl-Methyl)-5-Fluoroaniline is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We adhere to cGMP guidelines for the production of pharmaceutical intermediates to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.