Description

tert-Butyl 1-(Tetrahydro-2H-Pyran-4-Yl)Piperidin-4-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a complex piperidine-pyran hybrid scaffold. This compound is critical for medicinal chemistry research and development, enabling the synthesis of novel drug candidates with targeted biological activity. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in the production of active pharmaceutical ingredients (APIs) for central nervous system (CNS) and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug molecules, particularly for central nervous system (CNS) targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Custom Synthesis: Serves as a starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Protease Inhibitor Development: The structural motif is relevant in the design of protease inhibitors, a major class of pharmaceuticals.
• Chemical Biology Probes: Utilized to create specialized molecular probes for studying biological pathways and target validation.
• Scale-up API Manufacturing: Suitable for process development and cGMP-compliant scale-up to kilogram and multi-kilogram quantities for clinical trial material.

Basic Information

Product Name	tert-Butyl 1-(Tetrahydro-2H-Pyran-4-Yl)Piperidin-4-Ylcarbamate
CAS No.	873537-63-4
Molecular Formula	C15H28N2O3
Molecular Weight	284.40 g/mol
Synonyms	4-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-(tetrahydro-2H-pyran-4-yl)piperidine; 1-Boc-4-amino-1-(tetrahydro-2H-pyran-4-yl)piperidine; tert-Butyl N-[1-(oxan-4-yl)piperidin-4-yl]carbamate; 1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine, N-Boc-protected; BOC-Piperidine-Pyran Intermediate; 873537-63-4; 4-(Boc-amino)-1-(tetrahydropyran-4-yl)piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-(Tetrahydro-2H-Pyran-4-Yl)Piperidin-4-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production can be aligned with cGMP guidelines for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.