Description

Amino-Peg12-T-Butyl Ester is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a reactive primary amine group and a protected carboxylic acid terminus. This compound is engineered to serve as a critical building block and linker in advanced bioconjugation and pharmaceutical development, enabling the precise modification of biomolecules. It is essential for researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and advanced material science who require reliable, well-defined PEGylation reagents to enhance solubility, stability, and pharmacokinetic properties of their products.

Application

• As a versatile heterobifunctional linker for the site-specific conjugation of peptides, proteins, and antibodies to drugs, dyes, or solid surfaces.
• In the synthesis of complex drug delivery systems, including antibody-drug conjugates (ADCs) and nanoparticle formulations.
• For modifying biomaterial surfaces to improve biocompatibility, reduce immunogenicity, and introduce functional groups for further coupling.
• In diagnostic assay development for creating stable, non-interfering linkages between capture molecules and signal-generating components.
• As a key intermediate in the production of custom PEG derivatives and specialized reagents for life science research.
• For the development of hydrogels and other advanced polymeric materials with tailored chemical and physical properties.

Basic Information

Product Name	Amino-Peg12-T-Butyl Ester
CAS No.	872340-65-3
Molecular Formula	C33H67NO15
Molecular Weight	717.88 g/mol
Synonyms	tert-Butyl 3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatetracontan-48-oate; 2,5,8,11,14,17,20,23,26,29,32,35-Dodecaoxa-38-azaoctatetracontan-48-oic acid, 1,1-dimethylethyl ester; Amino-PEG12-t-butyl ester; H2N-PEG12-COOtBu; α-Amino-ω-(tert-butoxycarbonyl)-dodecaethylene glycol; Boc-NH-PEG12-acid; 1-Amino-3,6,9,12,15,18,21,24,27,30,33,36-dodecaoxaoctatriacontan-38-oic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our Amino-Peg12-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.