Description

1-n-Boc-4-(3-Chlorophenyl)-4-Hydroxypiperidine is a high-purity, protected piperidine derivative serving as a critical advanced intermediate in modern organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to build novel nitrogen-containing heterocycles.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those targeting the central nervous system (CNS) and other therapeutic areas.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging its halogenated aromatic and heterocyclic structure.
• Chemical Biology & Proteomics: Serves as a precursor for designing molecular probes and enzyme inhibitors to study biological pathways.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the scalable production of bespoke compounds for client R&D programs.
• Academic Research: Utilized in university and institutional labs for methodological development in synthetic organic chemistry.
• Library Synthesis: A valuable starting material for generating diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	1-n-Boc-4-(3-Chlorophenyl)-4-Hydroxypiperidine
CAS No.	871112-37-7
Molecular Formula	C16H22ClNO3
Molecular Weight	311.80 g/mol
Synonyms	1-Boc-4-(3-chlorophenyl)-4-hydroxypiperidine; tert-Butyl 4-(3-chlorophenyl)-4-hydroxypiperidine-1-carboxylate; 4-(3-Chlorophenyl)-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 4-(3-Chlorophenyl)-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(3-chlorophenyl)-4-hydroxypiperidine; N-Boc-4-(3-chlorophenyl)-4-hydroxypiperidine; 871112-37-7
EINECS	Contact for details

Quality Control

Our 1-n-Boc-4-(3-Chlorophenyl)-4-Hydroxypiperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable performance in your sensitive synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.