Description

Methyl 3-(Trifluoromethyl)Pyrazine-2-Carboxylate is a high-value fluorinated pyrazine derivative, a crucial building block in advanced organic synthesis. Its structure, featuring a reactive ester group and a trifluoromethyl-substituted heterocycle, makes it indispensable for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized heterocyclic compounds for organic electronic materials, such as OLEDs and semiconductors.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.

Basic Information

Product Name	Methyl 3-(Trifluoromethyl)Pyrazine-2-Carboxylate
CAS No.	870787-05-6
Molecular Formula	C7H5F3N2O2
Molecular Weight	206.12 g/mol
Synonyms	Methyl 3-(trifluoromethyl)pyrazine-2-carboxylate; 3-(Trifluoromethyl)pyrazine-2-carboxylic acid methyl ester; 2-Pyrazinecarboxylic acid, 3-(trifluoromethyl)-, methyl ester; Methyl 3-trifluoromethylpyrazine-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 3-(Trifluoromethyl)Pyrazine-2-Carboxylate adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified against comprehensive specifications including identity (IR, NMR), purity (HPLC), and impurity profiling. A Certificate of Analysis (COA) detailing all test results is provided with each shipment, and we support audits and regulatory documentation for cGMP and ISO 9001 compliant supply chains.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.