Description

tert-Butyl 4-(4-Chloro-2-Formylphenyl)Tetrahydro-1(2H)-Pyrazinecarboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its specific benzaldehyde and piperazine-derived structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities and proprietary drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other specialized therapeutic areas.
• API Synthesis: Serves as a crucial precursor in the production route of complex Active Pharmaceutical Ingredients (APIs), where its formyl and chloro groups allow for further functionalization.
• Medicinal Chemistry Research: Used in research and development laboratories for structure-activity relationship (SAR) studies and the creation of focused compound libraries.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Contract Manufacturing (CMO): Supplied to Contract Manufacturing Organizations for the production of clinical trial materials and commercial drug substances.

Basic Information

Product Name	tert-Butyl 4-(4-Chloro-2-Formylphenyl)Tetrahydro-1(2H)-Pyrazinecarboxylate
CAS No.	869478-16-0
Molecular Formula	C16H21ClN2O3
Molecular Weight	324.80 g/mol
Synonyms	1-Boc-4-(4-Chloro-2-formylphenyl)piperazine; tert-Butyl 4-(4-chloro-2-formylphenyl)piperazine-1-carboxylate; 4-(4-Chloro-2-formylphenyl)-1-(tert-butoxycarbonyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(4-chloro-2-formylphenyl)piperazine; 869478-16-0; 4-(4-Chloro-2-formylphenyl)piperazine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4-Chloro-2-Formylphenyl)Tetrahydro-1(2H)-Pyrazinecarboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical pharmaceutical synthesis. All material is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, ensuring the product meets the stringent requirements for use in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen) for long-term storage to maintain optimal purity and stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.