Description

1-Boc-Azepane-4-Carboxylic Acid is a high-purity, protected amino acid derivative that serves as a critical building block in advanced organic synthesis. Its primary value lies in enabling the controlled construction of complex molecular architectures, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on new drug candidates, especially within the fields of central nervous system (CNS) therapeutics and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive molecules.
• Peptidomimetics & Constrained Peptides: Used to introduce the seven-membered azepane ring structure, modifying peptide backbones to enhance metabolic stability and bioavailability.
• Protease Inhibitor Development: Serves as a core scaffold or side-chain component in the design of inhibitors for various protease enzymes.
• Chemical Biology & Probe Synthesis: Employed in the creation of tool compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects requiring protected heterocyclic carboxylic acids.
• Academic Research: Utilized in university and institutional labs for methodological development in organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-Boc-Azepane-4-Carboxylic Acid
CAS No.	868284-36-0
Molecular Formula	C₁₃H₂₃NO₄
Molecular Weight	257.33 g/mol
Synonyms	4-Carboxyazepane-1-carboxylic acid tert-butyl ester; tert-Butyl 4-carboxyazepane-1-carboxylate; 1-(tert-Butoxycarbonyl)azepane-4-carboxylic acid; Azepane-4-carboxylic acid, 1-Boc-protected; Boc-Aze(4)-OH; 1-Boc-4-carboxyazepane; 1-N-Boc-azepane-4-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-Boc-Azepane-4-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, low-humidity environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.