Description

4-[Carboxy-(4-Methoxy-Phenyl)-Methyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride is a high-purity, advanced pharmaceutical intermediate crucial for modern drug discovery and development. This compound serves as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders. It is essential for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those containing a piperazine moiety.
• API Synthesis: Used in the research and development of Active Pharmaceutical Ingredients (APIs) for potential treatments in neurology and psychiatry.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value fine chemicals and bespoke molecular entities.

Basic Information

Product Name	4-[Carboxy-(4-Methoxy-Phenyl)-Methyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride
CAS No.	868260-17-7
Molecular Formula	C19H28N2O5 • HCl
Molecular Weight	400.90 g/mol
Synonyms	1-Boc-4-[(4-Methoxyphenyl)(carboxy)methyl]piperazine hydrochloride; tert-Butyl 4-[(4-methoxyphenyl)(carboxy)methyl]piperazine-1-carboxylate hydrochloride; 1-(tert-Butoxycarbonyl)-4-[(4-methoxyphenyl)(hydroxycarbonyl)methyl]piperazine hydrochloride; 4-[(4-Methoxyphenyl)(carboxy)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester hydrochloride; Boc-4-[(4-Methoxyphenyl)(COOH)Methyl]piperazine HCl
EINECS	Contact for details

Quality Control

Our 4-[Carboxy-(4-Methoxy-Phenyl)-Methyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.