Description

4-[Carboxy-(4-Fluoro-Phenyl)-Methyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride is a high-purity, advanced pharmaceutical intermediate crucial for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is valued for its role as a key building block in medicinal chemistry, enabling the development of targeted therapeutics. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel drug candidates, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a versatile building block for constructing novel chemical entities in drug discovery and lead optimization programs.
• Protease Inhibitor Synthesis: Used in the development of protease inhibitors, a class of therapeutics for treating viral infections and other diseases.
• Kinase Inhibitor Development: Employed as a structural component in the creation of kinase inhibitors for oncology and inflammatory disease targets.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic & Industrial R&D: Utilized in research laboratories for studying structure-activity relationships (SAR) and developing new synthetic methodologies.

Basic Information

Product Name	4-[Carboxy-(4-Fluoro-Phenyl)-Methyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride
CAS No.	868151-70-6
Molecular Formula	C18H25FN2O4 • HCl
Molecular Weight	396.86 g/mol (Free base: 360.41 g/mol)
Synonyms	4-[(4-Fluorophenyl)(carboxy)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester hydrochloride; 1-Boc-4-[(4-fluorophenyl)(carboxy)methyl]piperazine hydrochloride; tert-Butyl 4-[(4-fluorophenyl)(carboxy)methyl]piperazine-1-carboxylate hydrochloride; 4-[(4-Fluorobenzoyl)methyl]-1-Boc-piperazine hydrochloride (common misnomer); 1-N-Boc-4-[(4-fluorophenyl)(hydroxycarbonyl)methyl]piperazine HCl; 868151-70-6 (CAS); Boc-4-[(4-FP)(COOH)Methyl]piperazine•HCl
EINECS	Contact for details

Quality Control

Our 4-[Carboxy-(4-Fluoro-Phenyl)-Methyl]-Piperazine-1-Carboxylic Acid tert-Butyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D and pre-clinical development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support development with custom synthesis and can scale production under controlled environments to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.