Description

tert-Butyl 3-(Piperazin-1-yl)pyrrolidine-1-carboxylate is a high-purity, protected heterocyclic amine building block of significant importance in modern synthetic chemistry. Its core value lies in its dual functionality, incorporating both a piperazine and a pyrrolidine moiety, which are privileged scaffolds in medicinal chemistry. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Scaffold: Used to construct complex molecules targeting G-protein-coupled receptors (GPCRs), kinases, and other biological targets due to its piperazine-pyrrolidine core.
• Agrochemical Synthesis: Serves as a building block in the development of advanced pesticides and herbicides, where its nitrogen-rich structure can contribute to biological activity.
• Chemical Biology Probe Development: Utilized in the synthesis of tool compounds and probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in multi-step custom synthesis projects.
• Library Synthesis for High-Throughput Screening: An ideal starting material for generating focused libraries of compounds for biological screening campaigns.

Basic Information

Product Name	tert-Butyl 3-(Piperazin-1-yl)pyrrolidine-1-carboxylate
CAS No.	867265-71-2
Molecular Formula	C13H25N3O2
Molecular Weight	255.36 g/mol
Synonyms	1-Boc-3-(piperazin-1-yl)pyrrolidine; tert-Butyl 3-(1-piperazinyl)-1-pyrrolidinecarboxylate; 3-Piperazin-1-yl-pyrrolidine-1-carboxylic acid tert-butyl ester; 1-Pyrrolidinecarboxylic acid, 3-(1-piperazinyl)-, 1,1-dimethylethyl ester; 3-(Piperazin-1-yl)pyrrolidine-1-carboxylic acid tert-butyl ester; Boc-3-(piperazin-1-yl)pyrrolidine; 867265-71-2; 1-Boc-3-piperazin-1-yl-pyrrolidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 3-(Piperazin-1-yl)pyrrolidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with the standards expected for pharmaceutical research intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.